Alon2003bnt Tinkerer

==Biological networks: the tinkerer as an engineer==
<bibtex>
@misc{alon2003bnt,
  title={{Biological networks: the tinkerer as an engineer}},
  author={Alon, U.},
  journal={Science},
  volume={301},
  number={5641},
  pages={1866--1867},
  year={2003},
  publisher={American Association for the Advancement of Science}
}
</bibtex>

This is a short position paper, in which Alon presents three of his research interests as evolutionary design principles.

===quotes===
"Recently, there have been detailed experimental-theoretical studies that demonstrate how particular gene circuis can be robust, for example, in bacterial chemotaxis (link, link) and in fruit-fly development (link3)."
*link1=Barkai, Leibler Nature 1997
*link2=Alon Surette Barkai, Leibler, Nature 1999
*link3=Eldar et al Nature 2002

most valuable:
"It is important to stress that the similarity in circuit structure does not necessarily stem from circuit duplication.  Evolution, be constant tinkering, appears to convere again and again on these cicuit patterns in different nonhomoloous systems (link1, link2, link3), presumable because the carry out key cuntions (link4)."
*link1=Shen-Orr, Milo, Mangan, Alon, Nature Genet 2002
*link2=Milo et al Science 2002
*link3=Conant, Wagner, Nature Genet 2003
*link4=Wagner Sci STKE 2003

[[Category::Citations To Read]]