Seth at 19:34, 24 June 2009

2009-06-24T19:34:01Z

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==An Analytically Solvable Model for Rapid Evolution of Modular Structure==
<bibtex>@article{kashtan2009asm,
title={{An Analytically Solvable Model for Rapid Evolution of Modular Structure}},
author={Kashtan, N. and Mayo, A.E. and Kalisky, T. and Alon, U.},
journal={PLoS Computational Biology},
volume={5},
number={4},
year={2009},
publisher={Public Library of Science}
}
</bibtex>

Neat paper, related to a 2002 Lipson paper making a matrix transform argument for modularity.

===Main Findings of past research:===
#A constant goal (that does not change over time) leads to non-modular structure.
#Modularly varying goals lead to modular structures.
#Evolution converges under MVG much faster than under a constant goal.
#The harder the goals, the faster the speedup observed in MVG relative to constant goal evolution.
#Random (non-modular) goals that vary over time usually lead to evolutionary confusion without generating modular structure, and rarely lead to speedup

===Other notes===
Much in complex systems gets into tradeoffs, and must take the cost of complexity into account. citations 24-26 are referenced in this paper as if they calculate the cost of protein production in e coli:
#Dekel, alon 2005 Optimality and evolutinary tuning of the expression level of a protein Nature
#Kock 1983 The protein burden of lac operon products J Mol Evol
#Nguyen, Phan, Duong, Bertrand, Lenski (1989) Effects of carriage and expression of the Tn10 tetracycline-resistance operon on the fitness of e coli K12. Mol Biol Evol.

The approach they offer visulizing(actually, characterizing) the dynamics and effects of modularly varying evolution is very clever and useful. Worth looking at the pictures. I haven't sat down with the math of it, but I maybe followed %20 on the first read.

Kashtan2009asm Analytically Solvable Model Modular Structure - Revision history

Seth at 19:34, 24 June 2009