Kashtan2009asm Analytically Solvable Model Modular Structure
From enfascination
An Analytically Solvable Model for Rapid Evolution of Modular Structure
<bibtex>@article{kashtan2009asm,
title=Template:An Analytically Solvable Model for Rapid Evolution of Modular Structure, author={Kashtan, N. and Mayo, A.E. and Kalisky, T. and Alon, U.}, journal={PLoS Computational Biology}, volume={5}, number={4}, year={2009}, publisher={Public Library of Science}
} </bibtex>
Neat paper, related to a 2002 Lipson paper making a matrix transform argument for modularity.
Main Findings of past research:
- A constant goal (that does not change over time) leads to non-modular structure.
- Modularly varying goals lead to modular structures.
- Evolution converges under MVG much faster than under a constant goal.
- The harder the goals, the faster the speedup observed in MVG relative to constant goal evolution.
- Random (non-modular) goals that vary over time usually lead to evolutionary confusion without generating modular structure, and rarely lead to speedup
Other notes
Much in complex systems gets into tradeoffs, and must take the cost of complexity into account. citations 24-26 are referenced in this paper as if they calculate the cost of protein production in e coli:
- Dekel, alon 2005 Optimality and evolutinary tuning of the expression level of a protein Nature
- Kock 1983 The protein burden of lac operon products J Mol Evol
- Nguyen, Phan, Duong, Bertrand, Lenski (1989) Effects of carriage and expression of the Tn10 tetracycline-resistance operon on the fitness of e coli K12. Mol Biol Evol.
The approach they offer visulizing(actually, characterizing) the dynamics and effects of modularly varying evolution is very clever and useful. Worth looking at the pictures. I haven't sat down with the math of it, but I maybe followed %20 on the first read.